Friday Program

Education Session | Lunch Debates | EHA / ESH Joint Symposium | Meet-the-Expert | Opening Ceremony | Molecular Hematopoiesis Workshop | Poster Session I

MOLECULAR HEMATOPOIESIS WORKSHOP
14:15 – 17:30, Hall C1

PART I – TRANSCRIPTION
Chair: D Tenen (Harvard Medical School, Boston, USA)

EPIGENETIC REGULATION IN HEMATOPOIETIC COMMITMENT
H Jorgensen (Medical Research Council, London, United Kingdom)

ABERRANT ACTIVATION OF SCL/TAL1 IN THE THYMUS PERTURBS NORMAL T-CELL DEVELOPMENT
J Göthert (University Hospital of Essen, Essen, Germany)

LEF-1 AND ITS ROLE IN LEUKEMOGENESIS
C Buske (Klinikum Großhadern, Munich, Germany)

FUNCTIONAL DISSECTION OF PROTEIN COMPLEXES ASSOCIATED WITH CHIMERIC TRANSCRIPTION FACTORS IN ACUTE MYELOID LEUKEMIA
E So (The Institute of Cancer Research, London, United Kingdom)

TRANSCRIPTIONAL REGULATION OF THE TUMOR SUPPRESSOR GENE MTSS-1 BY BCR-ABL IN LEUKEMIC STEM CELLS
S Koschmieder (University of Münster, Munich, Germany)

SALL4 AND STEM CELLS
L Chai (Brigham and Women's Hospital, Boston, USA)

PART II – SIGNAL TRANSDUCTION
Chair: A Green (Cambridge Institute of Medical Research, Cambridge,
United Kingdom)

THE ROLE OF DISEASE ALLELES IN GENESIS OF LEUKEMIA STEM CELLS
G Gilliland (Harvard Medical School, Boston, USA)

MECHANISM OF ACTIVATION OF THE NUP214-ABL1 FUSION
J Cools (University of Leuven, Leuven, Belgium)

SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION (STAT)FACTORS - A BOTTLENECK IN BCR/ABL INDUCED MALIGNANCY?
V Sexl (Medical University of Vienna, Vienna, Austria)

PROTEOMIC AND PHOSPHOPROTEOMIC ANALYSES OF THE LEUKAEMIAS
R Unwin (University of Manchester, Manchester, United Kingdom)

ERYTHROCYTOSIS ASSOCIATED HIF2A MUTATIONS INCREASE PROTEIN STABILITY OF HIF-2ALPHA
M Percy (Belfast City Hospital, Belfast, Northern Ireland)

CONSITUTIONAL AND ACQUIRED TRISOMY 21 IN LEUKEMIAS - ARE THEY COMPARABLE?
S Izraeli (Sheba Medical Center Tel Hashomer, Ramat Gan, Israel)

PART III – REGULATION OF NORMAL AND LEUKEMIC STEM CELLS
Chair: T Enver (Weatherall Institute of Molecular Medicine, Oxford,
United Kingdom)

PML/RARA DOWNREGULATES C/EBPA IN THE LEUKEMIC STEM CELL COMPARTMENT IN ACUTE PROMYELOCYTIC LEUKEMIA
D Tenen (Harvard Medical School, Boston USA)

STEM CELL AGING
D Bryder (Lund University Hospital, Lund, Sweden)

TRANSCRIPTIONAL REGULATION OF LINEAGE COMMITMENT:LINKS TO ACUTE MYELOID LEUKEMIA
C Nerlov (European Molecular Biology Laboratory, Monterotondo, Italy)

DISSECTING HAEMOPOIESIS IN ACUTE MYELOID LEUKAEMIA
P Vyas (Weatherall Institute of Molecular Medicine, Oxford, United Kingdom)

DORMANT AND ACTIVATED STEM CELLS DURING HOMEOSTASIS INJURY AND CANCER
A Trumpp (ISREC Lausanne, Switzerland)

AGING AND LONGEVITY GENES IN HEMATOPOIETIC STEM CELLS
H Nakauchi (University of Tokyo, Tokyo, Japan)