Sunday, June 10

SIMULTANEOUS SESSIONS III

08:00 - 09:15 hours, Room: Mozart I

CHRONIC MYELOID LEUKEMIA - CLINICAL II

Chairs: G. Saglio (University of Turin, Turin, Italy)
P. Rousselot (Hôpital André Mignot, Le Chesney, France)

08:00 - 08:15
0858

COMPARABLE OUTCOME OF MATCHED RELATED AND UNRELATED DONOR STEM CELL TRANSPLANTATION FOR FIRST CHRONIC PHASE CHRONIC MYELOID LEUKEMIA IN THE PROSPECTIVE GERMAN CML III STUDY
M. Hummel, R. Hehlmann, M. Pfirrmann, A. Hochhaus, A. Reiter, H. Heimpel, A. Gratwohl, H.J. Kolb, D.W. Beelen (Universitätsklinikum Mannheim, Mannheim, Germany)

08:15 - 08:30
0859

DASATINIB 140 MG QD VS 70 MG BID IN ADVANCED-PHASE CML OR PH(+) ALL RESISTANT OR INTOLERANT TO IMATINIB: RESULTS FROM A RANDOMIZED, PHASE-III TRIAL (CA180035)
H. Dombret, O. Ottmann, Y. Goh, D.W. Kim, A. Charbonnier, F. Maloisel, C. Bokemeyer, D. Niederwieser, J. Van Tornout, A. Damokosh, J. Cortes (Hopital Saint-Louis, Paris, France)

08:30 - 08:45
0860

NILOTINIB IS ASSOCIATED WITH MINIMAL CROSS INTOLERANCE TO IMATINIB IN PATIENTS WITH IMATINIB-INTOLERANT PHILADELPHIA-POSITIVE CHRONIC MYELOGENOUS LEUKEMIA IN EITHER CHRONIC PHASE OR ACCELERATED PHASE
G. Rosti, A. Hochhaus, P. Le Coutre, M. Baccarani, K. Bhalla, G. Ossenkoppele, N. Gattermann, A. Haque, A. Weitzman, F. Giles, H. Kantarjian (Institute of Hematology and Oncology, Bologna, Italy)

08:45 - 09:00
0861

IN PATIENTS WITH CHRONIC MYELOGENEOUS LEUKEMIA (CML), RESPONSE DYNAMICS TO NILOTINIB AFTER IMATINIB FAILURE DEPEND ON THE TYPE OF BCR-ABL MUTATIONS
M. Mueller, S. Branford, J. Radich, D.W. Kim, G. Martinelli, G. Saglio, P. Erben, S. Soverini, T. Hughes, Y. Shou, A. Weitzman, M. Baccarani, A. Hochhaus (Med. Fakultaet Mannheim, Uni Heidelberg, Mannheim, Germany)

09:00 - 09:15
0862

COMPARISON OF DASATINIB TO HIGH-DOSE IMATINIB IN PATIENTS WHO EXPERIENCE IMATINIB FAILURE: RESULTS FROM A RANDOMIZED, PHASE-II TRIAL (CA180017, START-R)
G. Martinelli, P. Rousselot, T. Robak, T. Masszi, A. Skotnicki, A. Hellmann, T. Hughes, A. Countouriotis, D. Dejardin, B. Druker (Universita Di Bologna, Bologna, Italy)

SIMULTANEOUS SESSIONS

08:00 - 09:15 hours, Room: Mozart III

NON-HODGKIN'S LYMPHOMA - CLINICAL II

Chairs: A. Hagenbeek (Academic Medical Center, Amsterdam, The Netherlands)
R. Pettengell (St. George’s Hospital, London, United Kingdom)

08:00 - 08:15
0863

PRIMARY EXTRANODAL DIFFUSE LARGE B-CELL LYMPHOMAS (DLBCL) ARISING IN DISTINCT SITES OF HEAD AND NECK HAVE DIFFERENT CLINICAL CHARACTERISTICS AND OUTCOME
S. Cortelazzo, M. Mian, A. Rossi, E. Oldani, M.E. Cabrera, M. Federico, M. Bellei, S. Magrini, M. Buglione, M. Martelli, H. Gomez, A. Lopez-Guillermo, E. Pogliani, F. Rossini, G. Gidano, A. Conconi, M. Busetto, C. Visco, R. Tsang, E. Zucca, A. Rambaldi, F. Cavalli (Hematology BZ, Bolzano, Italy)

08:15 - 08:30
0864

THE CHARACTERISTICS AND CLINICAL COURSE OF MALTLYMPHOMA:
THE UNIVERSITY OF VIENNA EXPERIENCE
M. Raderer, M. Troch, S. Woehrer, B. Streubel, A. Puespoek, K. Turetschek, M. Formanek, U. Jaeger, W. Hauff, J. Drach, A. Chott (University of Vienna, Vienna, Austria)

08:30 - 08:45
0865

IDENTIFICATION OF NEOPLASTIC INFILTRATION OF THE CEREBROSPINAL FLUID (CSF) IN AGGRESSIVE B-NHL:
A MULTICENTER STUDY COMPARING THE UTILITY OF FLOW CYTOMETRY (FCM) VS CONVENTIONAL CYTOLOGY (CC)
S. Quijano (Centro de Investigación del Cáncer, Salamanca, Spain)

08:45 - 09:00
0866

HIGH INCIDENCE OF AUTOIMMUNE COMPLICATIONS IN 82 PATIENTS WITH NON-MALT MARGINAL ZONE LYMPHOMAS
M. Rinaldi, A. Ambrosetti, M. Bonifacio, M. Lestani, O. Perbellini, M.G. Zorzi, A. Bonani, I. Nichele, G. Quaresmini, G. Pizzolo (Poloclinico G.B. Rossi, Verona, Italy)

09:00 - 09:15
0867

COMPREHENSIVE GERIATRIC ASSESSMENT-ADAPTED CHEMOTHERAPY IN 100 ELDERLY PATIENTS (> 70 YEARS) WITH DIFFUSE LARGE B-CELL NON-HODGKIN’S LYMPHOMA (DLBCL)
M. Spina, M. Balzarotti, L. Uziel, A. Ferreri, L. Fratino, A. Giacalone, E. Vaccher, A. Santoro, U. Tirelli (National Cancer Institute, Aviano (pn), Italy)

SIMULTANEOUS SESSIONS

08:00 - 09:15 hours, Room: Strauss I

ACUTE MYELOID LEUKEMIA - BIOLOGY I

Chairs: A. Biondi (University of Milano-Bicocca, Milan, Italy)
H. Döhner (University of Ulm, Ulm, Germany)

08:00 - 08:15
0868

LESTAURTINIB INDUCES INCREASED CYTOTOXICITY IN PRIMARY AML BLASTS WITH A FLT3 INTERNAL TANDEM DUPLICATION COMPARED TO THOSE WITH WILD TYPE OR TYROSINE KINASE DOMAIN MUTATED FLT3
A. Mead, A. Khwaja, P. Kottaridis, D. Linch, R. Gale (UCL, London, United Kingdom)

08:15 - 08:30
0869

HIGH RESOLUTION SNP ARRAYS AND MIRNA GENE EXPRESSION REVEALS PREVIOUSLY UNIDENTIFIED ABERRATIONS IN PATIENTS WITH AML AND NORMAL KARYOTYPE
C. Vicente, I. Vazquez, E. Bandres, N. Marcotegui, G. Rivell, I. Cristobal, C. Carranza, M.J. Larrayoz, I. Lahortiga, M.J. Calasanz, M.D. Odero (Center for Applied Medical Research, Pamplona, Spain)

08:30 - 08:45
0870

SEGMENTAL UNIPARENTAL DISOMY IS THE MOST COMMONLY ACQUIRED GENETIC ABNORMALITY IN RELAPSED ACUTE MYELOID LEUKEMIA
M. Raghavan (Barts & the London School of Medicine, London, United Kingdom)

08:45 - 09:00
0871

DERIVATION OF A GLOBAL MAP OF DNA HOMOZYGOSITY IN ACUTE MYELOID LEUKEMIA (AML)
M. Gupta (Barts and The London, London, United Kingdom)

09:00 - 09:15
0872

MN1 INDUCES LEUKEMIA IN MICE AND PREDICTS ATRA RESISTANCE AND SENSITIVITY IN AML PATIENTS
M.H. Heuser, B. Argiropoulos, F. Kuchenbauer, E. Yung, J. Piper, S. Fung, R.F. Schlenk, K. Dohner, T. Hinrichsen, C. Rudolph, A. Schambach, C. Baum, B. Schlegelberger, H. Dohner, A. Ganser, R.K. Humphries (British Columbia Cancer Agency, Vancouver, Canada)

SIMULTANEOUS SESSIONS

08:00 - 09:15 hours, Room: Strauss II

ACUTE LYMPHOBLASTIC LEUKEMIA - BIOLOGY

Chairs: D. Hoelzer (University of Frankfurt, Frankfurt, Germany)
S. Izraeli (Sheba Medical Center, Ramat Gan, Israel)

08:00 - 08:15
0873

DIFFERENTIAL CHROMOSOMAL BREAKPOINTS IMPACT LEVEL OF LMO2 EXPRESSION IN T-ALL
A.W. Langerak, W.A. Dik, B. Nadel, G.K. Przybylski, V. Asnafi, P. Grabarczyk, J.M. Navarro, B. Verhaaf, C.A. Schmidt, E.A. Macintyre, J.J.M. Van Dongen (Erasmus MC, Rotterdam, The Netherlands)

08:15 - 08:30
0874

EVIDENCE FOR POSTNATAL ORIGIN OF CHILDHOOD T-LINEAGE ALL
R. Panzer-Grümayer, S. Fischer, G. Mann, M. Metzler, G. Ebetsberger, N. Jones, B. Nadel, O. Bodamer, O.A. Haas, K. Schmitt, H. Gadner (Children's Cancer Research Institute, Vienna, Austria)

08:30 - 08:45
0875

EML1-ABL1 IS ACTIVATED BY COILED COIL MEDIATED OLIGOMERIZATION AND INDUCES T-CELL ACUTE LYMPHOBLASTIC OR CHRONIC MYELOID LEUKEMIA IN A MOUSE BONE MARROW TRANSPLANT MODEL
K. De Keersmaecker, H. Verachtert, W. Landuyt, C. De Wolf-Peeters, P. Vandenberghe, J. Schwaller, P. Marynen, J. Cools (University of Leuven, Leuven, Belgium)

08:45 - 09:00
0876

ANALYSIS OF PAIRED PRESENTATION AND RELAPSE SAMPLES IN T-ALL SUGGESTS THAT, AT LEAST IN SOME PATIENTS, NOTCH- 1 MUTATIONS MAY BE ACQUIRED AS A SECONDARY EVENT
M. Mansour, V. Duke, B. Patel, P. Ancliff, L. Foroni, R.E. Gale, D.C. Linch (University College London, London, United Kingdom)

09:00 - 09:15
0877

PAX5/TEL TRANSDUCED PRE-BI CELLS ARE RESISTANT TO TGF-BETA1 AND MIGRATE TOWARDS SDF-1ALPHA
G. F. Fazio, C. Palmi, V. Andrè, A Biondi, A. Rolink, G. Cazzaniga (Tettamanti Reserach Center, Monza, Italy)

SIMULTANEOUS SESSIONS

08:00 - 09:15 hours, Room: Strauss III

THROMBOSIS AND BLEEDING DISORDERS

Chairs: R. Bertina (University Medical Center, Leiden, The Netherlands)
P. Mannucci (A. Bianchi Bonomi Center, Milan, Italy)

08:00 - 08:15
0878

SOLUBLE P-SELECTIN AND THROMBOSIS RISK OF PATIENTS WITH A PERSISTENT LUPUS ANTICOAGULANT IN A PROSPECTIVE COHORT STUDY
R. Vormittag, S. Panzer, C. Ay, P. Quehenberger, S. Koder, I. Pabinger (MUW, Vienna, Austria)

08:15 - 08:30
0879

P-SELECTIN GENE HAPLOTYPES MODULATE SOLUBLE PSELECTIN LEVELS AND CONTRIBUTE TO THE RISK OF VENOUS THROMBOEMBOLISM
C. Ay, L.V. Jungbauer, A. Kaider, S. Koder, S. Panzer, I. Pabinger, M. Mannhalter (Medical University Vienna, Vienna, Austria)

08:30 - 08:45
0880

A HIGH PLATELET COUNT INDEPENDENTLY PREDICTS VENOUS THROMBOEMBOLISM IN CANCER PATIENTS – RESULTS FROM THE VIENNA CANCER AND THROMBOSIS STUDY (CATS)
R. Simanek, R. Vormittag, G. Alguel, C. Ay, D. Dunkler, P. Quehenberger, C. Zielinski, U. Jäger, I. Pabinger (Medical University of Vienna, Vienna, Austria)

08:45 - 09:00
0881

INCIDENCE AND DETERMINANTS OF BLEEDING IN VON WILLEBRAND DISEASE: RESULTS OF THE FIRST PROSPECTIVE MULTICENTER STUDY ON 814 ITALIAN PATIENTS
A.B. Federici, P. Bucciarelli, G. Castaman, M.G. Mazzucconi, M. Morfini, A. Rocino, M. Schiavoni, F. Rodeghiero, P.M. Mannucci (University of Milan, Milan, Italy)

09:00 - 09:15
882

CISPLATIN INDUCES THROMBIN GENERATION VIA FORMATION OF PROCOAGULANT ENDOTHELIAL MICROPARTICLES IN VITRO
D. Lechner, M. Kollars, A. Gleiss, S. Eichinger, P.A. Kyrle, A. Weltermann (Medical University of Vienna, Vienna, Austria)

SIMULTANEOUS SESSIONS

08:00 - 09:15 hours, Room: Léhar III+IV

MYELOMA / MGUS / WM - BIOLOGY

Chairs: J. Drach (Medical University, Vienna, Austria)
G. Morgan (Royal Marsden Hospital, London, United Kingdom)

08:00 - 08:15
0883

IMPACT OF CONSOLIDATION WITH BORTEZOMIB, THALIDOMIDE AND DEXAMETHASONE ON RESIDUAL MULTIPLE MYELOMA CELLS AFTER AUTOLOGOUS TRANSPLANTATION ASSESSED BY QUALITATIVE AND QUANTITATIVE PCR
M. Ladetto, M. Astolfi, L. Santo, I. Avonto, F. Cavallo, G. Pagliano, P. Pregno, M. Grasso, A.M. Liberati, T. Caravita, F. Pisani, T. Guglielmelli, E. Genuardi, R. Crivelli, C. Cristiano, D. Drandi, M. Boccadoro, A. Palumbo (Università di Torino, Turin, Italy)

08:15 - 08:30
0884

THE PROTEASOME INHIBITOR BORTEZOMIB STIMULATES THE OSTEOGENIC DIFFERENTIATION OF HUMAN MYSENCHYMAL CELLS IN VITRO AND MAY RESTORE THE NUMBER OF OSTEOBLASTIC CELLS IN MULTIPLE MYELOMA PATIENTS
N. Giuliani, S. Tagliaferri, M. Lazzaretti, F. Morandi, M. Crugnola, S. Bonomini, C. Mancini, E. Martella, C. Colla, G. Sammarelli, V. Rizzoli (Hematology, Parma, Italy)

08:30 - 08:45
0885

ANGIOPOIETIN1/ANGIOPOIETIN2 RATIO IS REDUCED AND CORRELATES WITH DISEASE SEVERITY IN RELAPSED/REFRACTORY MYELOMA PATIENTS. NORMALIZATION OF THE RATIO POST BORTEZOMIB THERAPY
K. Anargyrou, E. Terpos, S. Sachanas, T. Tzenou, S. Masouridis, T. Christoulas, M.K. Angelopoulou, S.I. Kokoris, T.P. Vassilakopoulos, M.P. Siakantaris, C. Kalpadakis, P. Panayiotidis, K. Tsionos, G.A. Pangalis, M.C. Kyrtsonis (251 General Air force Hospital, Athens, Greece)

08:45 - 09:00
0886

STABLE ASYMPTOMATIC MYELOMA AND MGUS IN THE PRESENCE OF T(4;14)
M. Ross, L. Chiecchio, R.K.M. Protheroe, G.P. Dagrada, D.M. Stockley, M. Nightingale, N.C.P. Cross, C.J. Harrison, K.H. Orchard (University of Southampton, Salisbury, United Kingdom)

09:00 - 09:15
0887

DELETIONS OF CHROMOSOMES 6Q AND 13Q, AND TRISOMY 4 ARE THE MOST COMMON CYTOGENETIC ABNORMALITIES IN WALDENSTRÖM MACROGLOBULINEMIA. PRELIMINARY RESULTS OF A MULTICENTRIC STUDY
F. Nguyen-Khac, E. Chapiro, C. Barin, N. Gachard, A. Daudignon, C. Terre, V. Eclache, I. Luquet, V. Soenen, C. Henry, H. Mossafa, S. Ramond, B. Perissel, C. Bastard, S. Struski, C. Bilhou-nabera, M.-J. Gregoire, E. Callet-Bachu, M.-J. Mozziconacci, F. Mugneret, H. Merle-beral, V. Leblond (Hopital Pitie-Salpetriere, Paris, France)

SIMULTANEOUS SESSIONS

08:00 - 09:15 hours, Room: Stolz I

GENOMICS AND PROTEOMICS

Chairs: J. Cools (University of Leuven-VIB, Leuven, Belgium)
O. Hantschel (Austrian Academy of Science, Vienna, Austria)

08:00 - 08:15
0888

PHOSPHOPROTEOMIC PROFILING OF PEDIATRIC B-ALL PATIENTS USING REVERSE PHASE PROTEIN ARRAYS
B. Accordi, V. Espina, G. Te Kronnie, L. Liotta, E. Petricoin, III, G. Basso (University of Padua, Padova, Italy)

08:15 - 08:30
0889

MRNA EXPRESSION PROFILING IN ADULT ACUTE MYELOID LEUKEMIA IDENTIFIES DISTINCT SUBCLASSES
L. Bullinger, S. Sander, K. Holzmann, A. Russ, H. Kestler, J.R. Pollack, R.F. Schlenk, K. Dohner, H. Dohner (University of Ulm, Ulm, Germany)

08:30 - 08:45
0890

IDENTIFICATION OF CANDIDATE GENES IN HIGH-LEVEL DNA AMPLIFICATIONS IN AML WITH COMPLEX KARYOTYPE USING AN ARRAY-BASED APPROACH
F. Rucker, L. Bullinger, S. Miller, H. Kestler, P. Lichter, K. Dohner, H. Dohner (University of Ulm, Ulm, Germany)

08:45 - 09:00
0891

AN INTERNATIONAL MULTI-CENTER RESEARCH STUDY TO DEFINE THE APPLICATION OF MICROARRAYS IN THE DIAGNOSIS AND SUBCLASSIFICATION OF LEUKEMIA (MILE STUDY):
A REPORT ON 2926 CASES
T. Haferlach, A. Kohlmann, K. Mills, W.K. Hofmann, T. te Kronnie, G. Basso, J. Hernandez Rivas, J. Downing, A. Yeoh, J. De Vos, M.C. Béné, C. Preudhomme, E. Macintyre, T. Kipps, L. Wieczorek, R. Foa (MLL, Munich Leukemia Laboratory, Munich, Germany)

09:00 - 09:15
0892

INTEGRATION OF GENOME WIDE SNP ARRAYS AND GENE EXPRESSION DATA OF CHILDHOOD ALL WITHOUT KNOWN GENETIC ABERRATIONS IDENTIFY SUBGROUPS WITH SPECIFIC GENETIC HALLMARKS
S. Bungaro, M. Campo dell’Orto, D. Basso, A. Zangrando, T.A. Gorletta, M. Raghavan, A. Leszl, B.D. Young, G. Basso, S. Bicciato, G. Te Kronnie, A. Biondi, G. Cazzaniga (M.Tettamanti Research Center, Monza, Italy)

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