Simultaneous sessions Saturday June 17

SIMULTANEOUS SESSION

08:00 - 09:15, Auditorium

CHRONIC MYELOID LEUKEMIA
Chairs: J. Melo (Imperial College, London, United Kongdom) F. Pane (University of Naples, Naples, Italy)

08:00 - 08:15 0465 A RANDOMIZED STUDY OF DASATINIB VERSUS ESCALATED DOSE OF IMATINIB (IM) IN PATIENTS WITH CHRONIC PHASE CHRONIC MYELOID LEUKEMIA (CP-CML) RESISTANT TO IMATINIB. RESULTS OF CA180017 START-R STUDY
H. Kantarjian, P. Rousselot, D. Pasquini, N. Khoroshko, T. Robak, J. Holowiecki, B. Gerard, D. Dejardin, T. Hughes, N. Shah (MD Anderson Cancer Center, Houston, USA) 08:15 - 08:30 0466 LONG-TERM BENEFITS OF IMATINIB (IM) FOR PATIENTS NEWLY DIAGNOSED WITH CHRONIC MYELOGENOUS LEUKEMIA IN CHRONIC PHASE (CML-CP): THE 5- YEAR UPDATE FROM THE IRIS STUDY
F.G. Guilhot, R.A. Larson, S.G. O'Brien, B.J. Druker, On behalf of IRIS Study Group (University Hospital, Poitiers, France) 08:30 - 08:45 0467 A PHASE II STUDY OF DASATINIB IN PATIENTS WITH CHRONIC PHASE CHRONIC MYELOID LEUKEMIA (CP-CML) WHO ARE RESISTANT OR INTOLERANT TO IMATINIB: RESULTS OF THE CA180013 'START-C' STUDY
A. Hochhaus, H. Kantarjian, N. Shah, G. Rosti, F. Cervantes, T. Facon, A. Countouriotis, R. Ezzeddine, S. Branford, B. Druker (Universitaet Heidelberg, Mannheim, Germany) 08:45 - 09:00 0468 RESPONSE TO DASATINIB AFTER IMATINIB FAILURE ACCORDING TO TYPE OF PREEXISTING BCR-ABL MUTATIONS
M.C. Mueller, P. Erben, T. Schenk, S. Lauber, J. Kruth, J. Hoffmann, T. Ernst, M. Schatz, T. Lahaye, G. Metzgeroth, M. Acevedo, C. Nicaise, R. Hehlmann, A. Hochhaus (Universitaetsklinikum Mannheim, Mannheim, Germany) 09:00 - 09:15 0469 PREDICTIVE VALUE OF BCR-ABL TRANSCRIPT LEVELS AFTER 12 MONTHS OF IMATINIB MONOTHERAPY FOR THE OUTCOME OF CML PATIENTS AFTER 5 YEARS
M.C. Mueller, T. Schenk, P. Erben, T. Ernst, S. Lauber, J. Kruth, P. Paschka, T. Lahaye, U. Haus, R. Hehlmann, A. Hochhaus (Universitaetsklinikum Mannheim, Mannheim, Germany)

SIMULTANEOUS SESSION

08:00 - 09:15, Auditorium

ACUTE MYELOID LEUKEMIA
Chairs: G. Ossenkoppele (VU Medical Center, Amsterdam, The Netherlands) F. Lo Coco (University Tor Vergata, Rome, Italy)

08:00 - 08:15 0470 DOSE-DEPENDENT COMPETITION BETWEEN NPM LEUKEMIC MUTANTS AND ARF PROTEIN FOR SUBCELLULAR DISTRIBUTION: A NUCLEAR TUG-OF-WAR
N.B. Bolli, M.P. Martelli, B. Bigerna, A. Pucciarini, B. Verducci Galletti, M.T. Pallotta, M.F. De Marco, V. Pettirossi, R. Mannucci, I. Nicoletti, B. Falini (Universita' di Perugia, Perugia, Italy) 08:15 - 08:30 0471 A NOVEL MOLECULAR MECHANISM LEADING TO PRIMARY RESISTANCE TO FLT3-TYROSINE KINASE INHIBITORS IN AML BY FORMATION OF FLT3-ITD627E
F.B. Breitenbücher, T. Stauder, Y. Höhn, S. Schnittger, T. Kindler, F. Giles, E. Feldman, P.S. Cohen, G. Ehninger, G.J. Schiller, S. Nimer, R. Stone, T. Haferlach, C. Huber, T. Fischer (University Hospital Mainz, Mainz, Germany) 08:30 - 08:45 0472 MICROARRAY-BASED CHARACTERIZATION OF AML WITH COMPLEX KARYOTYPES DISCLOSE NOVEL GENOMIC IMBALANCES HARBORING NEW CANDIDATE GENES
F.G. Rücker, L. Bullinger, H.A. Kestler, P. Lichter, K. Döhner, H. Döhner (University of Ulm, Ulm, Germany) 08:45 - 09:00 0473 GENE EXPRESSION BASED CHARACTERIZATION OF NPM1-MUTATED/FLT3 ITD-NEGATIVE ACUTE MYELOID LEUKEMIA WITH NORMAL KARYOTYPE
L. Bullinger, K. Döhner, R. Kranz, M. Richter, F.G. Rucker, C. Scholl, S. Frohling, R.F. Schlenk, H. Döhner, J.R. Pollack (University of Ulm, Ulm, Germany) 09:00 - 09:15 0474 EFFECT OF MDR1 SINGLE NUCLEOTIDE POLYMORPHISMS (SNPS) C1236T, G2677T AND C3435T ON MDR1 FUNCTION AND EXPRESSION IN LEUKEMIC BLASTS, AND ON TREATMENT OUTCOME IN ELDERLY PATIENTS WITH AML
B. van der Holt, M.M. van den Heuvel-Eibrink, R.H.N. van Schaik, I.P. van der Heiden, E.A.C. Wiemer, P.J.M. Vossebeld, B. Löwenberg, P. Sonneveld (Erasmus MC / Daniel den Hoed Cancer Center, Rotterdam, The Netherlands)

SIMULTANEOUS SESSION

08:00 - 09:15 hours, Room B

STEM CELL BIOLOGY
Chairs: M. Alberich-Jorda (Harvard Institute of Medicine, Boston, USA) A. Migliaccio (Instituto Superoire Sanità, Rome, Italy)

08:00 - 08:15 0475 THE MOLECULAR SIGNATURE OF PURIFIED CANCER STEM CELLS REVEALS A STEM CELL ORIGIN OF 5Q- SYNDROME
L. Nilsson, P. Edén, E. Olsson, R. Månsson, I. Åstrand-Grundström, B. Strömbeck, K. Theilgaard-Mönch, R. Hast, E. Hellström-Lindberg, J. Samuelsson, G. Bergh, B. Johansson, M. Sigvardsson, Å. Borg, S.E.W. Jacobsen (Lund Stem Cell Center, Lund, Sweden) 08:15 - 08:30 0476 PROTEIN KINASE B (PKB/C-AKT): A MOLECULAR SWITCH IN REGULATION OF LINEAGE CHOICE DECISIONS DURING MYELOPOIESIS
M. Buitenhuis, L. Verhagen, H.W.M. van Deutekom, A. Castor, S. Verploegen, L. Koenderman, S.E. Jacobsen, P.J. Coffer (UMC Utrecht, Utrecht, The Netherlands) 08:30 - 08:45 0477 CONSTITUTIVE EXPRESSION OF THE 'LYMPHOID ENHANCER FACTOR 1' (LEF-1) PERTURBS HAEMATOPOIETIC DEVELOPMENT AND INDUCES LEUKEMIA IN A SUBSET OF TRANSPLANTED MICE
K. Petropoulos, F. Ahmed, C. Schessl, N. Arseni, W. Hiddemann, R. Grosschedl, M. Feuring-Buske, C. Buske (LMU University, GSF-Hämatologikum, Munich, Germany) 08:45 - 09:00 0478 ALTERED PROLIFERATION/DIFFERENTIATION POTENTIAL OF COMMON MEGAKARYOCYTIC-ERYTHROID PROGENITORS (MEP) FROM MICE CARRYNG THE HYPOMORPHIC GATA1 LOW MUTATION
A.R. Migliaccio, B. Ghinassi, M. Sanchez, F. Martelli, S.H. Orkin, G. Migliaccio (Istituto Superiore Sanità, Rome, Italy) 09:00 - 09:15 0479 CD97 IS DIFFERENTIALLY EXPRESSED ON MURINE HEMATOPOIETIC STEM CELLS AND PROGENITOR CELLS
M. van Pel, H. Hagoort, R. Willemze, J. Hamann, W.E. Fibbe (Leiden University Medical Center, Leiden, The Netherlands)

SIMULTANEOUS SESSION

08:00 - 09:15 hours, Room C

DENDRITIC CELLS, VACCINATION AND CELLULAR IMMUNOTHERAPY
Chairs: M. Phokakar (the Rockefeller University, New York, USA) F. Stevenson (University of Southampton, Southampton, United Kingdom)

08:00 - 08:15 0480 CLINICAL BENEFIT ASSOCIATED WITH IDIOTYPIC VACCINATION IN FOLLICULAR LYMPHOMA
M. Bendandi (University Clinic of Navarra, Pamplona, Spain) 08:15 - 08:30 0481 PRHAMM/CD168-R3 PEPTIDE VACCINATION OF HLA-A2+ PATIENTS WITH ACUTE MYELOID LEUKEMIA (AML), MYELODYSPLASTIC SYNDROME (MDS) AND MULTIPLE MYELOMA (MM) ELICITS IMMUNOLOGICAL AND HEMATOLOGICAL RESPONSES
J. Greiner, A. Schmitt, K. Giannopoulos, L. Li, P. Liebisch, C. Wendl, J. Chen, M. Ringhoffer, P. Guillaume, G. Ritter, H. Döhner, M. Schmitt (University of Ulm, Ulm, Germany) 08:30 - 08:45 0482 TRIGGERING OF P38 MAPK BY CONDITIONAL MKK6 INDUCTION IS SUFFICIENT FOR DENDRITIC CELL MATURATION, AN EFFECT FURTHER ENHANCED BY INHIBITION OF NUCLEAR RELB
A. Jörgl, B. Platzer, S. Taschner, B. Höcher, F. Göbel, H. Strobl (Medical University of Vienna, Vienna, Austria) 08:45 - 09:00 0483 THE IMMUNE RESPONSE TO BCR-ABL PEPTIDE IMMUNISATION IS VARIABLE AND TRANSIENT IN CHRONIC MYELOID LEUKAEMIA: RESULTS FROM THE EPIC STUDY
J.M. Rojas, K. Knight, L. Wang, C. Lucas, R.E. Clark (University of Liverpool, Liverpool, United Kingdom) 09:00 - 09:15 0484 MULTIPLE MYELOMA REACTIVE CYTOTOXIC T CELLS RECOGNIZE A NEW ACTIVATION INDUCED MINOR HISTOCOMPATIBILITY ANTIGEN ENCODED BY ATP DEPENDENT INTERFERON RESPONSIVE (ADIR) GENE
C.A.M. van Bergen, M.G.D. Kester, I. Jedema, M.H.M. Heemskerk, S.A.P. van Luxemburg-Heijs, F. Kloosterboer, W.A.F. Marijt, A.H. de Ru, M.R. Schaafsma, R. Willemze, P.A. van Veelen, J.H.F. Falkenburg (LUMC, Leiden, The Netherlands)

SIMULTANEOUS SESSION

08:00 - 09:15 hours, Room L

VASCULAR BIOLOGY AND GRANULOCYTES
Chairs: E. Papadaki (University Hospital of Heraklion, Heraklion, Greece) D. Lane (Imperial College, London, United Kingdom)

08:00 - 08:15 0485 INHIBITION OF HIF1-ALPHA BY A POTENT RNA ANTAGONIST IS ASSOCIATED WITH MULTIPLE MECHANISMS OF ANTI-TUMOUR ACTIVITY
P. Kearney, M. Westergaard, H.F. Hansen, C. Thrue, J.B. Hansen, T. Koch, H. Oerum (Santaris Pharma, Copenhagen, Denmark) 08:15 - 08:30 0486 T-CELL RECEPTOR VB REPERTOIRE ANALYSIS IN CHRONIC IDIOPATHIC NEUTROPENIA: EVIDENCE FOR PRESENCE OF PROMINENT T-CELL CLONES WITH PATHOGENETIC SIGNIFICANCE
M. Spanoudakis, H. Koutala, C. Gemetzi, G. Eliopoulos, H.A. Papadaki (University of Crete School of Medicine, Heraklion, Greece) 08:30 - 08:45 0487 CONCURRENT MUTATIONS IN NEUTROPHIL ELASTASE AND GRANULOCYTE COLONY-SIMULATING FACTOR RECEPTOR GENES IN A CASE OF SEVERE CONGENITAL NEUTROPENIA
C. Ward, A.C. Ward, R.S. Lewis, F. Majeed, S. Shigdar, A.A. Aprikyan, D.C. Dale, Y. Dror (Deakin University, Burwood, Australia) 08:45 - 09:00 0488 NEOPLASTIC CIRCULATING ENDOTHELIAL CELLS IN HEMATOLOGIC MALIGNANCIES
G.M. Rigolin, F. Fraulini, M. Ciccone, E. Mauro, O. Sofritti, C. De Angeli, M. Negrini, G. Castoldi, A. Cuneo (Hematology, Ferrara, Italy) 09:00 - 09:15 0489 EVIDENCE FOR DISTINCT PHENOTYPIC STAGES DURING ENDOTHELIAL PROGENITOR DIFFERENTIATION
S. Dias, C.I. Igreja, R. Fragoso, C. Real, C. Casalou, S. Constantino Rosa Santos, C. Appleton, A. Henriques, N. Clode, C.I. Igreja (Instituto Português de Oncologia, Lisboa, Portugal)

SIMULTANEOUS SESSION

08:00 - 09:15 hours, Room X

MULTIPLE MYELOMA - CLINICAL
Chair: H. Einsele (Julius-Maximilans Universität, Würzburg, Germany) H. Ludwig (Wilhelminenspital, Vienna, Austria)

08:00 - 08:15 0490 A PROSPECTIVE RANDOMIZED CONTROLLED TRIAL OF ORAL MELPHALAN, PREDNISONE, THALIDOMIDE VERSUS ORAL MELPHALAN, PREDNISONE IN ELDERLY NEWLY DIAGNOSED MYELOMA PATIENTS
PA. Palumbo, S. Bringhen, T. Caravita, V. Callea, R. Zambello, P. Pregno, A. Carubelli, A. Baraldi, C. Cellini, F. Dore, E. Piro, M.T. Ambrosini, P. Musto, A.M. Liberati, M. Boccadoro (Divisione di Ematologia Univ. Torino, Torino, Italy) 08:15 - 08:30 0491 ORAL REVLIMID(R) PLUS MELPHALAN AND PREDNISONE (R-MP) FOR NEWLY DIAGNOSED MULTIPLE MYELOMA: A PHASE I-II STUDY
A. Palumbo, P. Falco, P. Musto, P. Corradini, F. Di Raimondo, N. Giuliani, G. Rossi, F. Morabito, L. Canepa, A. Gozzetti, F. Gay, J. Zeldis, R. Knight, M. Boccadoro, M.T. Petrucci (Divisione di Ematologia Univ. Torino, Torino, Italy) 08:30 - 08:45 0492 HAEMATOLOGICAL PROFILES WITH BORTEZOMIB OR HIGH-DOSE DEXAMETHASONE TREATMENT IN RELAPSED MULTIPLE MYELOMA: PHASE 3 APEX TRIAL
S. Lonial, P. Richardson, P. Sonneveld, M. Schuster, D. Irwin, E. Stadtmauer, T. Facon, J.L. Harousseau, D. Ben-Yehuda, H. Goldschmidt, D. Reece, J. san Miguel, J. Bladé, M. Boccadoro, J. Cavenagh, K. Anderson (Winship Cancer Institute, Atlanta, USA) 08:45 - 09:00 0493 LENALIDOMIDE (REVLIMID) IN COMBINATION WITH DEXAMETHASONE (DEX) IS MORE EFFECTIVE THAN DEX ALONE IN PATIENTS WITH RELAPSED OR REFRACTORY MULTIPLE MYELOMA WHO HAVE RECEIVED PRIOR THALIDOMIDE THERAPY
J. Bladé, D. Weber, J. Zeldis, Z. Yu, A. Dmoszynska, M. Attal, J.L. Harousseau, A. Hellmann, M. Prince, J. San Miguel, A. Spencer, T. Cibeira, M. Dimopoulos, R. Knight (IDIBAPS, Hospital Clinic, Barcelona, Spain) 09:00 - 09:15 0494 LENALIDOMIDE (REVLIMID) COMBINATION WITH DEXAMETHASONE (DEX) IS MORE EFFECTIVE THAN DEX ALONE IN PATIENTS WITH RELAPSED OR REFRACTORY MULTIPLE MYELOMA AND INDEPENDENT OF NUMBER OF PREVIOUS TREATMENTS
M.A. Dimopoulos, A. Anagnostopoulos, M. Prince, J.L. Harrousseau, A. Dmoszynka, A. Hellmann, Z. Masliak, M. Lazzarino, T. Facon, R. Foa, J. Zeldis, Z. Yu, M. Olesnyckyj, H. Faleck, R. Knight (University of Athens School of Medicine, Athens, Greece)

SIMULTANEOUS SESSION

10:30 - 11:45 hours, Auditorium

CHRONIC MYELOPROLIFERATIVE DISORDERS
Chairs: R. Skoda (University Hospital Basel, Basel, Switzerland) N. Casadevall (Hôpital Hôtel Dieu, Paris, France)

10:30 - 10:45 0495 EVIDENCE THAT THE JAK2 V617F MUTATION AND MITOTIC RECOMBINATION OCCUR IN A LYMPHO-MYELOID PROGENITOR IN POLYCYTHAEMIA VERA AND IDIOPATHIC MYELOFIBROSIS
F. Delhommeau, I. Godin, A. Massé, C. Tonetti, S. Dupont, J.P. Le Couedic, N. Debili, P. Saulnier, N. Casadevall, W. Vainchenker, S. Giraudier (Inserm, Villejuif, France) 10:45 - 11:00 0496 INDOLENT MYELOFIBROSIS WITH MYELOID METAPLASIA: SPECIFIC CLINICAL FEATURES AND PROGNOSIS
M. Marchetti, C. Rognoni, R. Pastorino, U. Magrini, R. Invernizzi, G.L. Viarengo, P. Magni, R. Bellazzi, S. Quaglini, G. Bergamaschi, V. Rosti, M. Massa, G. Barosi, On behalf of the R.I.M.M. (IRCCS Policlinico San Matteo, Pavia, Italy) 11:00 - 11:15 0497 COEXPRESSION OF JAK2 V617F AND TYPE I CYTOKINE RECEPTORS IS NOT SUFFICIENT FOR CYTOKINE-INDEPENDENT CELL GROWTH
H. Quentmeier, C. Fischer, J. Reinhardt, M. Zaborski, H.G. Drexler (DSMZ, Braunschweig, Germany) 11:15 - 11:30 0498 ASSESSMENT OF MYELOID CLONALITY IN FEMALE PH-NEGATIVE MYELOPROLIFERATIVE DISORDERS BY JAK2V617F MUTATION AND HUMARA ASSAY
B. Bellosillo, E. Gimeno, R. Longarón, G. Navarro, L. Zamora, B. Espinet, E. Puigdecanet, A. Alvarez-Larrán, F. Solé, L. Florensa, S. Serrano, C. Besses (Hospital del Mar, Barcelona, Spain) 11:30 - 11:45 0499 ABERRANT GENE EXPRESSION PROFILE OF CD34+ CELLS IN IDIOPATHIC MYELOFIBROSIS IDENTIFIES A SUBSET OF DISEASEASSOCIATED GENES WITH CLINICAL CORRELATES
P. Guglielmelli, R Zini, C. Bogani, S. Salati, A. Pancrazzi, E. Bianchi, F. Mannelli, S. Ferrari, M.C. Le Bousse-Kerdilès, A.R. Migliaccio, A. Bosi, G. Barosi, R. Manfredini, A.M. Vannucchi (Az. Ospedaliero Universitaria Careggi, Florence, Italy)

SIMULTANEOUS SESSION

10:30 - 11:45 hours, Forum

ANTIBODIES IN THE TREATMENT OF NON-HODGKIN'S LYMPHOMA
Chairs: P.L. Zinzani (University of Bologna, Bologna, Italy) J. Schubert (Medical University Saarland, Homburg, Germany)

10:30 - 10:45 0500 HUMAX-CD20, A NOVEL FULLY HUMAN ANTI-CD20 MONOCLONAL ANTIBODY: RESULTS OF A PHASE I/II TRIAL IN RELAPSED OR REFRACTORY FOLLICULAR NON-HODGKIN'S LYMPHOMA
A. Hagenbeek, T. Plesner, P. Johnson, L. Pedersen, J. Walewski, A. Hellmann, B. Link, T. Robak, M. Wojtukiewicz, M. Pfreundschuh, M. Kneba, A. Engert, P. Sonneveld, M. Flensburg, J. Petersen, J. Radford (Academic Medical Center, Amsterdam, The Netherlands) 10:45 - 11:00 0501 ALEMTUZUMAB, FLUDARABINE, CYCLOPHOSPHAMIDE, AND DOXORUBICIN (CAMPATH-FCD): AN EFFECTIVE FIRST-LINE TREATMENT IN PERIPHERAL T-CELL LYMPHOMAS
E. Weidmann, G. Hess, S.W. Krause, M. Subklewe, M. Sökler, K. Weisel, J. Kruse, M. Dreyling, C. Falge, G. Hess, S.W. Krause, M. Subklewe, M. Sökler, K. Weisel, J. Kruse, M. Dreyling, C. Falge, E. Jager (Krankenhaus Nordwest, Frankfurt am Main, Germany) 11:00 - 11:15 0502 GALIXIMAB (ANTI-CD80 MONOCLONAL ANTIBODY) IN COMBINATION WITH RITUXIMAB FOR RELAPSED OR REFRACTORY, FOLLICULAR NHL: RESULTS OF A PHASE II STUDY
P. Leonard, J. Friedberg, A. Younes, D. Fisher, L. Gordon, J. Moore, M. Czuczman, T. Miller, P. Stiff, B. Cheson, A. Forero-Torres, B. McKinney, A. Molina (Weill Cornell Medical Center, New York, Ny, USA) 11:15 - 11:30 0503 MT103 (ANTI-CD19 X ANTI-CD3 BITE) INDUCES B CELL DEPLETION, CLEARANCE OF BONE MARROW INFILTRATION AND CLINICAL RESPONSES IN HEAVILY PRETREATED NHL PATIENTS: FIRST DATA FROM DOSE-ESCALATION STUDY MT103-104
R. Bargou, P. Kufer, P. Kirchinger, R. Noppeney, M. Schuler, A. Viardot, K. Weigang-Köhler, F. Zettl, C. Gerecke, M. Libicher, G. Riethmüller, R. Lutterbüse, M. Klinger, C. Reinhardt, P. Baeuerle (Medizinische Poliklinik, Würzburg, Germany) 11:30 - 11:45 0504 RITUXIMAB ADMINISTERED WITH MEGA-CHOEP HIGH-DOSE CHEMOTHERAPY AND AUTOLOGOUS TRANSPLANTATION OF HEMATOPOIETIC STEM CELLS IMPROVES OUTCOME FOR PATIENTS WITH DLBCL AND HIGH LDH
N. Schmitz, M. Kloess, M. Reiser, W.E. Berdel, B. Metzner, L. Truemper, M. Loeffler, M. Pfreundschuh, B. Glass (Asklepios Klinik St. Georg, Hamburg, Germany)

SIMULTANEOUS SESSION

10:30 - 11:45 hours, Room A

CANCER GENETICS AND CYTOGENETICS IN MYELOID DISEASES
Chairs: C. Harrison (University of Southampton, Southampton, United Kingdom) J. Cools (University of Leuven, Leuven, Belgium)

10:30 - 10:45 0505 GENE EXPRESSION PROFILING FOR MOLECULAR SUBCLASSIFICATION OF LEUKEMIA: INTERIM ANALYSIS OF THE INTERNATIONAL MULTI-CENTER STUDY (MILE) ON 1437 PATIENTS
T. Haferlach, A. Kohlmann, K. Mills, W.K. Hofmann, T. Kronnie, J. Hernandez Rivas, J. Downing, J. De Vos, M.C. Béné, C. Preudhomme, E. Macintyre, T. Kipps, L. Wieczorek, A.E. Yeoh, R. Foà (MLL, Munich Leukemia Laboratory, Munich, Germany) 10:45 - 11:00 0506 TRISOMY 8 IS ASSOCIATED WITH A HIGHER EXPRESSION OF A SUBSET OF GENES LOCATED ON CHROMOSOME 8 DETERMINED BY THE ACCOMPANYING GENETIC ABNORMALITIES
C. Schoch, A. Kohlmann, M. Dugas, W. Kern, S. Schnittger, T. Haferlach (MLL - Munich Leukemia Laboratory, Munich, Germany) 11:00 - 11:15 0507 JAK2 AND FLT3 MUTATION SCREENING IN 256 PATIENTS WITH AML/MDS AND A NORMAL KARYOTYPE. THE PRESENCE OF V617F CORRELATES WITH A HIGHER FREQUENCY OF CRYPTIC GENETIC ABERRATIONS
G. Rivell, I. Vazquez, C. Vicente, N. Marcotegui, A. Conchillo, C. Carranza, I. Cristobal, I. Lahortiga, J. Vizmanos, M. Calasanz, M. Odero (University of Navarra, Pamplona, Spain) 11:15 - 11:30 0508 GENETIC PATHWAYS OF THERAPY-RELATED MDS AND AML (T-MDS/T-AML)
J.P.B. Pedersen-Bjergaard, M.K.A Andersen, D.H.C Christiansen (Rigshospitalet, Copenhagen, Denmark) 11:30 - 11:45 0509 NEW STRATEGY TO IDENTIFY TUMOR SUPPRESSOR GENES IN ACUTE MYELOID LEUKEMIA (AML)
R. Beekman, M. Valkhof, S.J. Erkeland, I.P. Touw (Erasmus MC, Rotterdam, The Netherlands)

SIMULTANEOUS SESSION

10:30 - 11:45 hours, Room B

THROMBOSIS
Chairs: I. Pabinger (Medical University Vienna, Vienna, Austria) S. Schulman (McMaster University, Hamilton, Canada)

10:30 - 10:45 0510 ORAL CONTRACEPTIVE USE, THROMBOPHILIA AND THEIR INTERACTION FOR ISCHEMIC STROKE IN YOUNG WOMEN
TT. Battaglioli, I. Martinelli, I. Burgo, S. Di Domenico, P.M. Mannucci (IRCCS Maggiore Hospital, Milan, Italy) 10:45 - 11:00 0511 VENOUS THROMBOEMBOLISM - A METABOLIC DISEASE?
CC. Ay, T. Tengler, R. Simanek, R. Vormittag, T. Vukovich, I. Pabinger (AKH Wien, Internal Medicine I, Vienna, Austria) 11:00 - 11:15 0512 THE PERSISTANCE OF RESIDUAL VEIN THROMBOSIS, AFTER AN EPISODE OF DEEP VEIN THROMBOSIS, AND THE RISK OF NEW OVERT CANCER AND CARDIOVASCULAR DISEASE
S. Siragusa, A. Malato, R. Anastasio, M. Sciacca, V. Cigna, I. Abbene, L. Lo Coco, C. Arcara, F. Fulfaro, A. Casuccio (University of Palermo, Palermo, Italy) 11:15 - 11:30 0513 REGULATION OF PROTEIN S EXPRESSION BY SEX HORMONES
Q.H. Hughes, J.S. Staton, M.W. Watson, V.C. Cole, M.S. Sayer, R.B. Baker (University of Western Australia, Perth, Australia) 11:30 - 11:45 0514 RITUXIMAB IN THE TREATMENT OF ACUTE REFRACTORY AND CHRONIC RELAPSING THROMBOTIC THROMBOCYTOPENIC PURPURA: RESULTS FROM 28 PATIENTS
M.A. Scully, R. Liesner, J. Cavenagh, S. Benjamin, I. Mackie, S. Machin, H. Cohen (University College London, London, United Kingdom)

SIMULTANEOUS SESSION

10:30 - 11:45 hours, Room C

PAROXYSMAL NOCTURNAL HEMOGLOBINURIA AND FANCONI ANEMIA
Chairs: L. Luzzatto (University of Genova, Genova, Italy) J. Kushner (University of Utah Medical Center, Salt Lake City, USA)

10:30 - 10:45 0515 A RANDOMIZED CONTROLLED PROSPECTIVE CLINICAL STUDY COMPARING THE COMBINATION THERAPY OF DEFERIPRONE (L1) AND DESFERRIOXAMINE (DFO) WITH L1 AND DFO MONOTHERAPY IN PATIENTS WITH THALASSEMIA MAJOR
C.H. Manz, A. El-Beshlawy, Y. Aydinok, C. Leber, C. Czarnecki-Tarabishi (Lipomed AG, Arlesheim, Switzerland) 10:45 - 11:00 0516 THE CHALLENGE OF FANCONI ANEMIA DIAGNOSIS IN PATIENTS WITH BONE MARROW FAILURE
F. Pinto, T. Leblanc, G. Le Roux, M. Santos, J. Larghero, V. Rocha, H. Espérou, G. Socié, A. Baruchel, E. Gluckman, J. Soulier (Hôpital Saint-Louis, Paris, France) 11:00 - 11:15 0517 THE EFFECT OF COMBINED THERAPY WITH DEFEROXAMINE AND DEFERIPRONE ON MYOCARDIAL IRON AND ENDOTHELIAL FUNCTION IN THALASSEMIA MAJOR: A RANDOMIZED CONTROLLED TRIAL USING CARDIOVASCULAR MAGNETIC RESONANCE
M.A. Tanner, R. Galanello, C. Dessi, G.C. Smith, M.A. Westwood, A. Agus, R. Assomull, S.V. Nair, J.M. Walker, D.J. Pennell (Royal Brompton Hospital, London, United Kingdom) 11:15 - 11:30 0518 PAROXYSMAL NOCTURNAL HAEMOGLOBINURIA: LONG-TERM EPIDEMIOLOGICAL STUDY
R. Peffault de Latour, J.Y. Mary, C. Salanoubat, L. Terriou, G. Etienne, M. Mohty, S. Roth, S. De Guibert, J.Y. Cahn, G. Socié (Hôpital Saint- Louis, Paris, France) 11:30 - 11:45 0519 HIGH PREVALENCE OF PULMONARY HYPERTENSION AND HEMOLYSIS ASSOCIATED NITRIC OXIDE DEPLETION IN PATIENTS WITH PAROXYSMAL NOCTURNAL HEMOGLOBINURIA
A. Hill, X. Wang, R.J. Sapsford, G.M. McGawley, D.L. Oxborough, S.J. Richards, H. Kroon, R.P. Rother, M.T. Gladwin, P. Hillmen (Leeds General Infirmary, Leeds, United Kingdom)

SIMULTANEOUS SESSION

10:30 - 11:45 hours, Room L

CELL SIGNALLING, TRANSCRIPTIONAL CONTROL AND APOPTOSIS - I
Chairs: A. Trumpp (Swiss Institute for Experimental Cancer Research, Epalines, Switzerland) C. Reindl (GSF-Hämatologikum, Munich, Germany)

10:30 - 10:45 0520 ONTOGENY, FUNCTION AND PERIPHERAL HOMEOSTASIS OF REGULATORY T CELLS IN THE ABSENCE OF INTERLEUKIN-7
R. Peffault de Latour, H. Dujardin, F. Mishellany, J. Zuber, O. Burlen-Defranoux, R. Marques, A. Cumano, P. Vieira, A. Bandeira (Hôpital Saint-Louis, Paris, France) 10:45 - 11:00 0521 LYSOSOMAL ROUTING OF G-CSF RECEPTORS DEPENDS ON A SINGLE MEMBRANE-PROXIMAL LYSINE RESIDUE, IS CONTROLLED BY SOCS3 AND PLAYS A CRITICAL ROLE IN G-CSF-INDUCED GRANULOPOIESIS
M. Irandoust, J. Gits, O. Roovers, M. Valkhof, I. Touw, L. Aarts (Erasmus Medical Center, Rotterdam, The Netherlands) 11:00 - 11:15 0522 TRANSLATION OF IGBP1 MRNA CONTRIBUTES TO THE REGULATION OF EXPANSION AND DIFFERENTIATION OF ERYTHROID PROGENITORS
G. Grech, M. Blázquez-Domingo, H. Beug, B. Löwenberg, M. Von Lindern (Erasmus MC, Rotterdam, The Netherlands) 11:15 - 11:30 0523 EXPRESSION OF THE TEL-AML1 LEUKEMIA-ASSOCIATED FUSION PROTEIN INHIBITS TGF-BETA1 SIGNALING
C. Palmi, P. Cardus, A. Novosel, A. Biondi, M. Greaves, A. Ford (Institute of Cancer Research, London, United Kingdom) 11:30 - 11:45 0524 ONCOGENIC CBL MUTANTS CONFER A TRANSFORMING POTENTIAL TO HEMATOPOIETIC CELLS EXPRESSING THE FLT3 TYROSINE KINASE
C. Reindl, W. Hiddemann, K. Spiekermann (GSF-Hämatologikum, Munich, Germany)

SIMULTANEOUS SESSION

10:30 - 11:45 hours, Room X

MULTIPLE MYELOMA - CLINICAL / EXPERIMENTAL
Chairs: M. Boccadoro (San Giovanni, Battista Hospital, Turin, Italy) J.F. San Miguel (University of Salamanca, Salamanca, Spain)

10:30 - 10:45 0525 MYELOABLATIVE ALLOGENEIC STEM CELL TRANSPLANTATION AS PART OF FIRST-LINE THERAPY FOR DE NOVO MULTIPLE MYELOMA : LONG-TERM FOLLOW-UP OF PATIENTS REGISTERED IN THE FRENCH SOCIETY OF STEM CELL TRANSPLANTATION DATABASE (SFGM-TC)
P. Moreau, J.P. Jouet, M. Kuentz, G. Marit, M. Attal, F. Garban, N. Milpied, A. Buzyn, M. Michallet, J.H. Bourhis, D. Blaise, N. Ifrah, J.Y. Cahn, I. Yakoub-Agha, J.L. Harousseau, J.P. Vernant (University Hospital, Nantes, France) 10:45 - 11:00 0526 NEW CRITERIA TO IDENTIFY RISK OF PROGRESSION IN SMOLDERING MULTIPLE MYELOMA: MULTIPARAMETRIC FLOW CYTOMETRY ANALYSIS OF BONE MARROW PLASMA CELLS
E. Pérez Persona, B. Vidriales, G. Mateo, M.V. Mateos, A. García, J. Galende, G. Nuñez, J.M. Alonso, N. de las Heras, J.M. Hernández, A. Martín, C. Berges, J.J. Mateos, O. López, A. Orfao, J.F. San Miguel (Hospital Universitario de Salamanca, Salamanca, Spain) 11:00 - 11:15 0527 A MULTICENTER, RANDOMIZED TRIAL OF ZOLEDRONATE VS OBSERVATION IN EARLY-STAGE, ASYMPTOMATIC MYELOMA
P. Musto, A. Falcone, G. Sanpaolo, M.L. Barone, R. Guariglia, C. Musto, L. Ciuffreda, G. Pietrantuono, M.T. Petrucci, V. Bongarzoni, T. Guglielmelli, S. Bringhen, T. Caravita, P. Niscola, A. Andriani, G. D'Arena, E. Balleari, A. Palumbo, G. D'Arena (CROB, Rionero, Italy) 11:15 - 11:30 0528 ARRAY-CGH DETECTS FREQUENT RECURRENT IMBALANCES IN PLASMA CELL DISORDERS (PCD)
D. Drandi, M. Ladetto, M. El Ali, L. Santo, I. Ricca, M. Dell'Aquila, L. Monitillo, S. Li Bergolis, M. Boi, A. Rocci, C. Lobetti Bodoni, M. Astolfi, M.T. Ambrosini, P. Omede', A. Palumbo, M. Boccadoro (University of Torino, Torino, Italy) 11:30 - 11:45 0529 HYPERDIPLOIDY AND HYPODIPLOIDY IN MONOCLONAL GAMMOPATHY OF UNDETERMINED SIGNIFICANCE (MGUS) AND MULTIPLE MYELOMA (MM), AND THEIR RELATIONSHIPS WITH MONOSOMY 13
M. Zandecki, M. Brousseau, X. Leleu, J. Gerard, T. Gastine, A. Godon, F. Genevieve, M. Dib, J. Andrieux, T. Facon (CHU Angers, Angers, France)